Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity
During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
[HTML][HTML] Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Y Dong, H Chen, J Gao, Y Liu, J Li, J Wang - Journal of molecular and …, 2019 - Elsevier
Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …
Census and evaluation of p53 target genes
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …
gene alters its response pathway, and is central to the development of many cancers. The …
The tumor suppressor protein p53 and the ferroptosis network
Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …
Crosstalk between mammalian autophagy and the ubiquitin-proteasome system
Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …
human cancers. p53 functions during cancer progression have been linked to a variety of …
Autophagy and mitophagy in cardiovascular disease
Autophagy contributes to the maintenance of intracellular homeostasis in most cells of
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4
Ferroptosis is a newly characterized form of programmed cell death, which is driven by the
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …
Targeting autophagy to overcome drug resistance: further developments
H Chang, Z Zou - Journal of hematology & oncology, 2020 - Springer
Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …