The new neurometabolic cascade of concussion

CC Giza, DA Hovda - Neurosurgery, 2014 - journals.lww.com
Since the original descriptions of postconcussive pathophysiology, there has been a
significant increase in interest and ongoing research to study the biological underpinnings of …

The neuropathology of traumatic brain injury

AC Mckee, DH Daneshvar - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury, a leading cause of mortality and morbidity, is divided into three
grades of severity: mild, moderate, and severe, based on the Glasgow Coma Scale, the loss …

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

MS Subbarayan, A Joly-Amado, PC Bickford… - Pharmacology & …, 2022 - Elsevier
Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Injured brains and adaptive networks: the benefits and costs of hyperconnectivity

FG Hillary, JH Grafman - Trends in cognitive sciences, 2017 - cell.com
A common finding in human functional brain-imaging studies is that damage to neural
systems paradoxically results in enhanced functional connectivity between network regions …

[HTML][HTML] Neuroimaging after mild traumatic brain injury: review and meta-analysis

C Eierud, RC Craddock, S Fletcher, M Aulakh… - NeuroImage: Clinical, 2014 - Elsevier
This paper broadly reviews the study of mild traumatic brain injury (mTBI), across the
spectrum of neuroimaging modalities. Among the range of imaging methods, however …

The epidemiology and impact of traumatic brain injury: a brief overview

JA Langlois, W Rutland-Brown… - The Journal of head …, 2006 - journals.lww.com
Traumatic brain injury (TBI) is an important public health problem in the United States and
worldwide. The estimated 5.3 million Americans living with TBI-related disability face …

Functional connectivity in mild traumatic brain injury

AR Mayer, MV Mannell, J Ling… - Human brain …, 2011 - Wiley Online Library
Objectives: Research suggests that the majority of mild traumatic brain injury (mTBI) patients
exhibit both cognitive and emotional dysfunction within the first weeks of injury, followed by …

Post concussion syndrome

LM Ryan, DL Warden - International review of psychiatry, 2003 - Taylor & Francis
Individuals sustaining mild traumatic brain injuries often report a constellation of physical,
cognitive, and emotional/behavioral symptoms referred to as post concussion symptoms …

Factors moderating neuropsychological outcomes following mild traumatic brain injury: A meta-analysis

HG Belanger, G Curtiss, JA Demery… - Journal of the …, 2005 - cambridge.org
There continues to be debate about the long-term neuropsychological impact of mild
traumatic brain injury (MTBI). A meta-analysis of the relevant literature was conducted to …

Use of graded exercise testing in concussion and return-to-activity management

JJ Leddy, B Willer - Current sports medicine reports, 2013 - journals.lww.com
Concussion is a physiologic brain injury that produces systemic and cognitive symptoms.
The metabolic and physiologic changes of concussion result in altered autonomic function …