The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …

The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

The development dynamics and self-organization of glandular branched epithelia is of
utmost importance for our understanding of diverse processes ranging from normal tissue …

In the search for the ideal model of tumours, the use of three-dimensional in vitro models is
advancing rapidly. These are intended to mimic the in vivo properties of the tumours which …

An accumulation of previous work has established organoids as good preclinical models of
human tumors, facilitating translation from basic research to clinical practice. They are …

Drug combination therapies for cancer treatment show high efficacy but often induce severe
side effects, resulting in dose or cycle number reduction. We investigated the impact of …

In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural
heterogeneity increases chemoresistance and mortality rates. However, such morphological …

Personalized in vitro models for dysplasia and carcinogenesis in the pancreas have been
constrained by insufficient differentiation of human pluripotent stem cells (hPSCs) into the …