Molecular and evolutionary processes generating variation in gene expression
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …
variation arises from mutations that alter the form or function of molecular gene regulatory …
Determinants of nucleosome positioning
Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …
Here we review the dominant patterns of nucleosome positioning that have been observed …
[HTML][HTML] Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
JR Teijaro, KB Walsh, S Cahalan, DM Fremgen… - Cell, 2011 - cell.com
Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …
Determinants of nucleosome organization in primary human cells
Nucleosomes are the basic packaging units of chromatin, modulating accessibility of
regulatory proteins to DNA and thus influencing eukaryotic gene regulation. Elaborate …
regulatory proteins to DNA and thus influencing eukaryotic gene regulation. Elaborate …
Comparative studies of gene expression and the evolution of gene regulation
The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …
Chromatin and transcription in yeast
Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …
transcription has been an intense area of investigation for the past 25 years. Many of the key …
High-resolution nucleosome map** reveals transcription-dependent promoter packaging
Genome-wide map** of nucleosomes has revealed a great deal about the relationships
between chromatin structure and control of gene expression, and has led to mechanistic …
between chromatin structure and control of gene expression, and has led to mechanistic …
What controls nucleosome positions?
E Segal, J Widom - Trends in Genetics, 2009 - cell.com
The DNA of eukaryotic genomes is wrapped in nucleosomes, which strongly distort and
occlude the DNA from access to most DNA-binding proteins. An understanding of the …
occlude the DNA from access to most DNA-binding proteins. An understanding of the …
Identification of a large set of rare complete human knockouts
Loss-of-function mutations cause many mendelian diseases. Here we aimed to create a
catalog of autosomal genes that are completely knocked out in humans by rare loss-of …
catalog of autosomal genes that are completely knocked out in humans by rare loss-of …
Epigenetic responses to environmental change and their evolutionary implications
BM Turner - … Transactions of the Royal Society B …, 2009 - royalsocietypublishing.org
Chromatin is a complex of DNA, RNA, histones and non-histone proteins and provides the
platform on which the transcriptional machinery operates in eukaryotes. The structure and …
platform on which the transcriptional machinery operates in eukaryotes. The structure and …