Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men

CL Sexton, JS Godwin, MC McIntosh, BA Ruple… - Cells, 2023 - mdpi.com
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA
responses to one bout of lower load (LL) versus higher load (HL) resistance exercise …

Skeletal muscle memory

AP Sharples, DC Turner - American Journal of Physiology …, 2023 - journals.physiology.org
Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise

VC Figueiredo, Y Wen, B Alkner… - The Journal of …, 2021 - Wiley Online Library
Key points Ribosome biogenesis and MYC transcription are associated with acute
resistance exercise (RE) and are distinct from endurance exercise in human skeletal muscle …

A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle

RG Jones III, A Dimet‐Wiley, A Haghani… - The Journal of …, 2023 - Wiley Online Library
Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …

Impact of physical activity and exercise on the epigenome in skeletal muscle and effects on systemic metabolism

J Plaza-Diaz, D Izquierdo, Á Torres-Martos, AT Baig… - Biomedicines, 2022 - mdpi.com
Exercise and physical activity induces physiological responses in organisms, and
adaptations in skeletal muscle, which is beneficial for maintaining health and preventing …

Impact of exercise and aging on mitochondrial homeostasis in skeletal muscle: roles of ROS and epigenetics

J Li, Z Wang, C Li, Y Song, Y Wang, H Bo, Y Zhang - Cells, 2022 - mdpi.com
Aging causes degenerative changes such as epigenetic changes and mitochondrial
dysfunction in skeletal muscle. Exercise can upregulate muscle mitochondrial homeostasis …

Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health

TL Chambers, A Dimet‐Wiley, AR Keeble… - The Journal of …, 2024 - Wiley Online Library
Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of
exercise on muscle in a preclinical setting, we developed a combined endurance …