DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Metal drugs and the anticancer immune response

B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Reprogramming of tumor-associated macrophages with anticancer therapies: radiotherapy versus chemo-and immunotherapies

G Genard, S Lucas, C Michiels - Frontiers in immunology, 2017 - frontiersin.org
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

Molecular repolarisation of tumour-associated macrophages

FJ Van Dalen, MHME Van Stevendaal, FL Fennemann… - Molecules, 2018 - mdpi.com
The tumour microenvironment (TME) is composed of extracellular matrix and non-mutated
cells supporting tumour growth and development. Tumour-associated macrophages (TAMs) …

Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma

H Luo, H Zhang, J Mao, H Cao, Y Tao, G Zhao… - Cell Death & …, 2023 - nature.com
Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular
communication by reciprocally transporting DNA, RNA, bioactive protein, chains of glucose …

A DNA/DMXAA/Metal–Organic Framework Activator of Innate Immunity for Boosting Anticancer Immunity

X Chen, Q Tang, J Wang, Y Zhou, F Li, Y **e… - Advanced …, 2023 - Wiley Online Library
Immunotherapy has achieved revolutionary success in clinics, but it remains challenging for
treating hepatocellular carcinoma (HCC) characterized by high vascularization. Here, it is …

Organelle-specific triggered release of immunostimulatory oligonucleotides from intrinsically coordinated DNA–metal–organic frameworks with soluble exoskeleton

Z Wang, Y Fu, Z Kang, X Liu, N Chen… - Journal of the …, 2017 - ACS Publications
DNA has proven of high utility to modulate the surface functionality of metal–organic
frameworks (MOFs) for various biomedical applications. Nevertheless, current methods for …

Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases

LA Dykman - Expert review of vaccines, 2020 - Taylor & Francis
Introduction Vaccination remains very effective in stimulating protective immune responses
against infections. An important task in antibody and vaccine preparation is to choose an …

Ultrasound-triggered cascade reaction via MnO2-CpG nanoparticles for boosting pyroptosis-mediated cancer immunotherapy

X Wang, M Shen, Y Sun, Q Tang, L Du, S Yang, H Zou… - Nano Today, 2024 - Elsevier
Nanoparticles is promising for enhancing cancer immunotherapy efficacy via the regulation
of tumor microenvironment (TME), but the efficiency of regulation remains challenging …

Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy

Y Tao, E Ju, J Ren, X Qu - Biomaterials, 2014 - Elsevier
Graphene oxide (GO) has attracted tremendous research interest due to its excellent
electrical, thermal, and mechanical properties. Here, we apply the polyethylene glycol (PEG) …