The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Most cells in the body acquire iron via receptor-mediated endocytosis of transferrin, the
circulating iron transport protein. When cellular iron levels are sufficient, the uptake of …

L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Antagonists of L-type Ca2+ channels (LTCCs) have been used to treat human
cardiovascular diseases for decades. However, these inhibitors can have untoward effects …

Timothy Syndrome (TS) is caused by very rare exonic mutations of the CACNA1C gene that
produce delayed inactivation of Cav1. 2 voltage-gated calcium channels during cellular …

Steroid hormones bind receptors in the cell nucleus and in the cell membrane. The most
widely studied class of steroid hormone receptors are the nuclear receptors, named for their …

We have previously shown that the expression of voltage-operated Ca++ channels (VOCCs)
is highly regulated in the oligodendroglial lineage and is essential for proper …

We have found a significant upregulation of L‐type voltage‐operated Ca++ channels
(VOCCs) in reactive astrocytes. To test if VOCCs are centrally involved in triggering astrocyte …

L-type voltage-gated calcium channels are involved in multiple physiological functions.
Currently available antagonists do not discriminate between L-type channel isoforms …

Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …