Periodontitis: a multifaceted disease of tooth-supporting tissues

E Könönen, M Gursoy, UK Gursoy - Journal of clinical medicine, 2019 - mdpi.com
Periodontitis is an infection-driven inflammatory disease in which the composition of biofilms
plays a significant role. Dental plaque accumulation at the gingival margin initiates an …

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment

AD Kostic, E Chun, L Robertson, JN Glickman… - Cell host & …, 2013 - cell.com
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses
indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma …

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

E Gómez-Bañuelos, A Mukherjee, E Darrah… - Journal of clinical …, 2019 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by
immune-mediated damage of synovial joints and antibodies to citrullinated antigens …

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

M Zepeda-Rivera, SS Minot, H Bouzek, H Wu… - Nature, 2024 - nature.com
Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely
found in the lower gastrointestinal tract of healthy individuals, is enriched in human …

Changes in abundance of oral microbiota associated with oral cancer

BL Schmidt, J Kuczynski, A Bhattacharya, B Huey… - PloS one, 2014 - journals.plos.org
Individual bacteria and shifts in the composition of the microbiome have been associated
with human diseases including cancer. To investigate changes in the microbiome …

Oral microbial dysbiosis and its performance in predicting oral cancer

SC Su, LC Chang, HD Huang, CY Peng… - …, 2021 - academic.oup.com
Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma
(OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral …

Fap2 of Fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation, cell adhesion, and preterm birth

S Coppenhagen-Glazer, A Sol, J Abed… - Infection and …, 2015 - Am Soc Microbiol
Fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known
to translocate and cause intrauterine infections. In the oral environment, F. nucleatum …

Fusobacterium Species and Subspecies Differentially Affect the Composition and Architecture of Supra- and Subgingival Biofilms Models

T Thurnheer, L Karygianni, M Flury… - Frontiers in …, 2019 - frontiersin.org
Fusobacteria are common obligately anaerobic Gram-negative bacteria of the oral cavity
that may act as a bridge between early and late colonizing bacteria in dental plaque and …

Fusobacterium nucleatum Accelerates Atherosclerosis via Macrophage-Driven Aberrant Proinflammatory Response and Lipid Metabolism

J Zhou, L Liu, P Wu, L Zhao, Y Wu - Frontiers in Microbiology, 2022 - frontiersin.org
Periodontitis, an oral chronic inflammatory disease, is reported to show an association with
atherosclerotic vascular disease. Fusobacterium nucleatum is an oral commensal bacterium …

Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis?

S Ji, YS Choi, Y Choi - Journal of periodontal research, 2015 - Wiley Online Library
Periodontitis is chronic inflammation of the periodontium caused by the host's inflammatory
response to plaque biofilm, which destroys tooth‐supporting soft and hard tissues …