Recent work in structural biology is shedding light on how many of the enzymes of
intermediary metabolism are self-and co-assembling into large, filamentous polymers or …

During tumor evolution, cancer cells can acquire the ability to proliferate, invade neighboring
tissues, evade the immune system, and spread systemically. Tracking this process remains …

Chemigenetic fusion of synthetic dyes with genetically encoded protein tags presents a
promising avenue for in vivo imaging. However, its full potential has been hindered by the …

Recordings of the physiological history of cells provide insights into biological processes, yet
obtaining such recordings is a challenge. To address this, we introduce a method to record …

Recent advances in de novo protein design have delivered a diversity of discrete de novo
protein structures and complexes. A new challenge for the field is to use these designs …

Long-term memories are stored as configurations of neuronal ensembles, termed engrams.
Although investigation of engram cell properties and functionality in memory recall has been …

Microbial rhodopsin–derived genetically encoded voltage indicators (GEVIs) are powerful
tools for map** bioelectrical dynamics in cell culture and in live animals. Förster …

A paradigm for biology is emerging in which cells can be genetically programmed to write
their histories into their own genomes. These records can subsequently be read, and the …

Highlights•Molecular recorders capture transcriptional activity within the genome of
cells.•Transcriptional activity is recorded by linking a signal of interest to a DNA …

Technological advances have driven many recent advances in developmental biology. Light
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …