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Induced protein degradation: an emerging drug discovery paradigm
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …
directly affects protein function, and this approach typically precludes targeting proteins that …
The impact of transposable elements in adaptive evolution
L Schrader, J Schmitz - Molecular Ecology, 2019 - Wiley Online Library
The growing knowledge about the influence of transposable elements (TE s) on (a) long‐
term genome and transcriptome evolution;(b) genomic, transcriptomic and epigenetic …
term genome and transcriptome evolution;(b) genomic, transcriptomic and epigenetic …
The Hsp70/Hsp90 chaperone machinery in neurodegenerative diseases
RE Lackie, A Maciejewski, VG Ostapchenko… - Frontiers in …, 2017 - frontiersin.org
The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …
Molecular chaperones in protein folding and proteostasis
FU Hartl, A Bracher, M Hayer-Hartl - Nature, 2011 - nature.com
Most proteins must fold into defined three-dimensional structures to gain functional activity.
But in the cellular environment, newly synthesized proteins are at great risk of aberrant …
But in the cellular environment, newly synthesized proteins are at great risk of aberrant …
Molecular chaperone functions in protein folding and proteostasis
The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Abstract Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that
facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched …
facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched …
Targeting the dynamic HSP90 complex in cancer
J Trepel, M Mollapour, G Giaccone, L Neckers - Nature reviews cancer, 2010 - nature.com
The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to
facilitate the function of numerous oncoproteins, and it can be argued that cancer cells …
facilitate the function of numerous oncoproteins, and it can be argued that cancer cells …
Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress
B Chen, ME Feder, L Kang - Molecular ecology, 2018 - Wiley Online Library
Heat‐shock proteins (Hsps) and their cognates are primary mitigators of cell stress. With
increasingly severe impacts of climate change and other human modifications of the …
increasingly severe impacts of climate change and other human modifications of the …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have
been implicated in different aspects of cancer cell survival and metastasis. Here, we …
been implicated in different aspects of cancer cell survival and metastasis. Here, we …