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Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …
spaceflight and that have been known to cause physiological changes in humans over a …
[HTML][HTML] Detection and prediction of osteoarthritis in knee and hand joints based on the X-ray image analysis
Current assessment of osteoarthritis (OA) is primary based on visual grading of joint space
narrowing and osteophytes present on radiographs. The approach is observer-dependent …
narrowing and osteophytes present on radiographs. The approach is observer-dependent …
Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
M Bellido, L Lugo, JA Roman-Blas, S Castañeda… - Arthritis research & …, 2010 - Springer
Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …
[HTML][HTML] In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model
F Intema, HAW Hazewinkel, D Gouwens… - Osteoarthritis and …, 2010 - Elsevier
OBJECTIVE: The pathogenesis of osteoarthritis (OA) includes cartilage degeneration,
synovial inflammation, and bone changes. Slowly, the sequence and inter-relationship of …
synovial inflammation, and bone changes. Slowly, the sequence and inter-relationship of …
Pre-flight exercise and bone metabolism predict unloading-induced bone loss due to spaceflight
Objectives Bone loss remains a primary health concern for astronauts, despite in-flight
exercise. We examined changes in bone microarchitecture, density and strength before and …
exercise. We examined changes in bone microarchitecture, density and strength before and …
[HTML][HTML] Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT
OBJECTIVE: To characterize the rabbit anterior cruciate ligament transection (ACLT) model
of osteoarthritis (OA) at various stages of disease using high-resolution 3-D medical imaging …
of osteoarthritis (OA) at various stages of disease using high-resolution 3-D medical imaging …
Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
Preclinical osteoarthritis (OA) models are often employed in studies investigating disease-
modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal …
modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal …
[HTML][HTML] Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study
OBJECTIVES: We evaluated the three-dimensional (3D) micro-architecture of subchondral
trabecular (Tb) bone in osteoarthritis (OA). Due to high signal-to-noise ratio and high …
trabecular (Tb) bone in osteoarthritis (OA). Due to high signal-to-noise ratio and high …
High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST …
Objectives: Previous studies suggest that high systemic bone mineral density (BMD) is
associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint …
associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint …
Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis
JR Matyas, L Atley, M Ionescu… - … : Official Journal of the …, 2004 - Wiley Online Library
Objective To study 3 body fluids for changes in the levels of 5 biomarkers of cartilage
metabolism during the early phases of experimental osteoarthritis (OA). Methods Twenty …
metabolism during the early phases of experimental osteoarthritis (OA). Methods Twenty …