Background In breast cancer, immunohistochemical assessment of proliferation using the
marker Ki67 has potential use in both research and clinical management. However, lack of …

Aberrant glycosylation is a universal feature of cancer cells, and cancer‐associated glycans
have been detected in virtually every cancer type. A common change in tumour cell …

BACKGROUND Breast cancer and its treatment can have an impact on health-related
quality of life and survival. Tumour profiling tests aim to identify whether or not women need …

Histopathology plays a central role in diagnosis of many diseases including solid cancers.
Efforts are underway to transform this subjective art to an objective and quantitative science …

Abstract Analysis of publicly available genomic and gene expression data demonstrates that
MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl …

Prostate cancer is the most common cancer in men and it is estimated that over 350,000
men worldwide die of prostate cancer every year. There remains an unmet clinical need to …

Aggressive behaviours of solid tumours are highly influenced by the tumour
microenvironment. Multiple signalling pathways can affect the normal function of stromal …

Purpose To evaluate locally versus centrally assessed estrogen (ER) and progesterone
(PgR) receptor status and the impact of PgR on letrozole adjuvant therapy compared with …

Non-small-cell lung cancer patients with activating epidermal growth factor receptor (EGFR)
mutations typically benefit from EGFR tyrosine kinase inhibitor treatment. However, virtually …

Background: The discovery of ERG/ETV 1 gene rearrangements and PTEN gene loss
warrants investigation in a mechanism-based prognostic classification of prostate cancer …