Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Tumors generate physical forces during growth and progression. These physical forces are
able to compress blood and lymphatic vessels, reducing perfusion rates and creating …

For almost four decades, my work has focused on one challenge: improving the delivery and
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

The lymphatic vasculature is not considered a formal part of the immune system, but it is
critical to immunity. One of its major roles is in the coordination of the trafficking of antigen …

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are
known to exert both pro-and anti-tumour effects. We summarize our current understanding of …

Advances in our understanding of the structure and function of the lymphatic system have
made it possible to identify its role in a variety of disease processes. Because it is involved …

Chronic liver disease is associated with remarkable alterations in the intra-and extrahepatic
vasculature. Because of these changes, the fields of liver vasculature and portal …

Microcirculation (2010) 17, 206–225. doi: 10.1111/j. 1549‐8719.2010. 00029. x Abstract
Intravital imaging techniques have provided unprecedented insight into tumor …