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Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
Neuroinflammation: an astrocyte perspective
Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …
in health and disease. Recent technologies have uncovered the functional heterogeneity of …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …
a wide range of functions. The enormous diversity and intricate organization of cells have …
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration
Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …
A concerted neuron–astrocyte program declines in ageing and schizophrenia
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …
cellular terms. Here we describe a relationship between people's cortical neurons and …
A conceptual framework for astrocyte function
The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …
Astrocyte morphology
KT Baldwin, KK Murai, BS Khakh - Trends in cell biology, 2024 - cell.com
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …
feature of astrocytes is their complex and visually enchanting morphology, referred to as …
[HTML][HTML] Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
Memory encodes past experiences, thereby enabling future plans. The basolateral
amygdala is a centre of salience networks that underlie emotional experiences and thus has …
amygdala is a centre of salience networks that underlie emotional experiences and thus has …