The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of
potentially dual-specific protein kinases is among several that regulate a number of steps of …

Plants and animals mediate early steps of the innate immune response through pathogen
recognition receptors (PRRs). PRRs commonly associate with or contain members of a …

The spindle checkpoint assures the proper segregation of chromosomes during mitosis. The
best-characterized components of the checkpoint were originally identified in budding yeast …

Compromising the activity of the spindle checkpoint permits mitotic exit in the presence of
unattached kinetochores and, consequently, greatly increases the rate of aneuploidy in the …

The vertebrate kinetochore is a complex structure that specifies the attachments between the
chromosomes and microtubules of the spindle and is thus essential for accurate …

Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), a rapidly progressing, clonal malignancy of CD4+ T lymphocytes. Fewer than one in …

Tumorigenesis is a consequence of loss of tumor suppressors and activation of oncogenes.
Expression of the mitotic checkpoint protein Chfr is lost in 20–50% of primary tumors and …

Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated
with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid …

Abstract Treatment of cells with microtubule inhibitors results in activation of the mitotic
spindle assembly checkpoint, leading to mitotic arrest before anaphase. Upon prolonged …