Immune aging–A mechanism in autoimmune disease

Y Zheng, Q Liu, JJ Goronzy, CM Weyand - Seminars in immunology, 2023 - Elsevier
Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

Calreticulin: Endoplasmic reticulum Ca2+ gatekeeper

M Michalak - Journal of Cellular and Molecular Medicine, 2024 - Wiley Online Library
Endoplasmic reticulum (ER) luminal Ca2+ is vital for the function of the ER and regulates
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …

Interplay between calcium and endoplasmic reticulum stress

J Groenendyk, M Michalak - Cell Calcium, 2023 - Elsevier
Cellular homeostasis is crucial for the healthy functioning of the organism. Disruption of
cellular homeostasis activates endoplasmic reticulum (ER) stress co** responses …

The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids

X Liu, C Yang, P Chen, L Zhang, Y Cao - Science of the Total Environment, 2022 - Elsevier
The potential uses of graphene-based nanomaterials (NMs) in various fields lead to the
concern about their neurotoxicity, considering that graphene-based NMs are capable to …

The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi

A Mizuike, S Sakai, K Katoh, T Yamaji… - Journal of Cell …, 2023 - rupress.org
Phosphatidylinositol 4-monophosphate [PtdIns (4) P] is a precursor for various
phosphoinositides but also a membrane-embedded component crucial for membrane …

A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets

RK Angara, A Sadi, SD Gilk - EMBO reports, 2024 - embopress.org
Effective intracellular communication between cellular organelles occurs at dedicated
membrane contact sites (MCSs). Tether proteins are responsible for the establishment of …

The key roles of organelles and ferroptosis in Alzheimerʼs disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Journal of …, 2022 - Wiley Online Library
Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global
health problem. Ferroptosis is a newly discovered form of cell death characterized by iron …

The progress and future of the treatment of Candida albicans infections based on nanotechnology

Y Gao, Q Cao, Y **ao, Y Wu, L Ding, H Huang… - Journal of …, 2024 - Springer
Systemic infection with Candida albicans poses a significant risk for people with weakened
immune systems and carries a mortality rate of up to 60%. However, current therapeutic …

Endoplasmic reticulum membrane contact sites: cross-talk between membrane-bound organelles in plant cells

J Bian, X Su, X Yuan, Y Zhang, J Lin… - Journal of Experimental …, 2023 - academic.oup.com
Eukaryotic cells contain organelles surrounded by monolayer or bilayer membranes.
Organelles take part in highly dynamic and organized interactions at membrane contact …

Antioxidants and mechanistic insights for managing dry age-related macular degeneration

D Basyal, S Lee, HJ Kim - Antioxidants, 2024 - mdpi.com
Age-related macular degeneration (AMD) severely affects central vision due to progressive
macular degeneration and its staggering prevalence is rising globally, especially in the …