The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn
with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation …

Migraine is a chronic neurological disorder that affects approximately 12% of the population.
The cause of migraine headaches is not yet known, however, when the trigeminal system is …