The origin of life is still one of humankind's great mysteries. At the transition between
nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain …

Conspectus As the remit of chemistry expands beyond molecules to systems, new synthetic
targets appear on the horizon. Among these, life represents perhaps the ultimate synthetic …

Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of
life. However, little is known about protocell's survival and fitness under prebiotic radiations …

Conspectus Creating a living system from nonliving matter is a great challenge in chemistry
and biophysics. The early history of life can provide inspiration from the idea of the prebiotic …

There is currently no plausible path for the emergence of a self-replicating protocell,
because prevalent formulations of model protocells are built with fatty acid vesicles that …

Living systems create complex structures and functions by mastering self‐organization in a
variety of equilibrium and non‐equilibrium states. Mimicking the dynamical phenomena with …

General structure of metabolism includes the reproduction of catalysts that govern
metabolism. In this structure, the system becomes autopoietic in the sense of Maturana and …

In nature, chemotactic interactions are ubiquitous and play a critical role in driving the
collective behavior of living organisms. Reproducing these interactions in vitro is still a …

All known forms of life are composed of cells, whose boundaries are defined by lipid
membranes that separate and protect cell contents from the environment. It is unknown how …

Abstract Systems of catalytic RNAs presumably gave rise to important evolutionary
innovations, such as the genetic code. Such systems may exhibit particular tolerance to …