Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Musculoskeletal pain is a challenging condition for both patients and physicians. Many
adults have experienced one or more episodes of musculoskeletal pain at some time of their …

Objective To update and expand upon prior Osteoarthritis Research Society International
(OARSI) guidelines by develo** patient-focused treatment recommendations for …

Importance Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic …

The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Importance Research into acupuncture and acupressure and their application for cancer
pain has been growing, but the findings have been inconsistent. Objective To evaluate the …

Background Knee osteoarthritis (OA) is a chronic progressive disease that imparts a
substantial socioeconomic burden to society and healthcare systems. The prevalence of …

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …