Metagenomics is a discipline that enables the genomic study of uncultured microorganisms.
Faster, cheaper sequencing technologies and the ability to sequence uncultured microbes …

For nearly three decades, the sequence of the human mitochondrial genome (mtDNA) has
provided a molecular framework for understanding maternally inherited diseases. However …

Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an
ongoing, global, community-driven effort to evaluate and improve the computational …

High-quality and high-throughput prediction of enzyme commission (EC) numbers is
essential for accurate understanding of enzyme functions, which have many implications in …

Detection of protein homology via sequence similarity has important applications in biology,
from protein structure and function prediction to reconstruction of phylogenies. Although …

Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …

Motivation: Metagenomics is the study of genetic material recovered directly from
environmental samples. Taxonomic and functional differences between metagenomic …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

In recent years, ontologies have become a mainstream topic in biomedical research. When
biological entities are described using a common schema, such as an ontology, they can be …

With the development of next generation sequencing techniques, it is fast and cheap to
determine protein sequences but relatively slow and expensive to extract useful information …