Potential therapeutic options for COVID-19: an update on current evidence

Z Niknam, A Jafari, A Golchin, F Danesh Pouya… - European journal of …, 2022 - Springer
Abstract SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19
pandemic and is a major public health concern nowadays. The rapid and global spread of …

[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Y Gupta, OV Savytskyi, M Coban, A Venugopal… - Molecular Aspects of …, 2023 - Elsevier
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

How to use COVID-19 antiviral drugs in patients with chronic kidney disease

A Kale, V Shelke, N Dagar, HJ Anders… - Frontiers in …, 2023 - frontiersin.org
Antiviral drugs such as Remdesivir (Veklury), Nirmatrelvir with Ritonavir (Paxlovid),
Azvudine, and Molnupiravir (Lagevrio) can reduce the risk for severe and fatal Coronavirus …

An overview of SARS-CoV-2 potential targets, inhibitors, and computational insights to enrich the promising treatment strategies

P Kumawat, LK Agarwal, K Sharma - Current Microbiology, 2024 - Springer
The rapid spread of the SARS-CoV-2 virus has emphasized the urgent need for effective
therapies to combat COVID-19. Investigating the potential targets, inhibitors, and in silico …

Voltammetric determination of daclatasvir dihydrochloride at bimetallic Ag/Co nanoparticles modified carbon paste electrode

SS Badawy, YM Ahmed, MA Sultan - Microchemical Journal, 2023 - Elsevier
In this work, a sensitive and cost-effective voltammetric method was proposed for the
determination of daclatasvir dihydrochloride (DAC. 2HCl) at a bimetallic Ag/Co …

Effect of sofosbuvir-based treatment on clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials

CK Hsu, CY Chen, WC Chen, CC Lai, SH Hung… - International Journal of …, 2022 - Elsevier
This systematic review and meta-analysis examined the efficacy of sofosbuvir-based
antiviral treatment against COVID-19 (coronavirus disease 2019). PubMed, Embase …

Targeting emerging RNA viruses by engineered human superantibody to hepatitis C virus RNA-dependent RNA polymerase

K Glab-Ampai, K Kaewchim, T Thavorasak… - Frontiers in …, 2022 - frontiersin.org
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across
all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this …

A pharmacometric approach to evaluate drugs for potential repurposing as COVID-19 therapeutics

T Wattanakul, P Chotsiri, I Scandale… - Expert Review of …, 2022 - Taylor & Francis
Introduction Develo** and evaluating novel compounds for treatment or prophylaxis of
emerging infectious diseases is costly and time-consuming. Repurposing of already …

Dibenzo-18-crown-6-based carbon paste sensors for the nanomolar potentiometric determination of daclatasvir dihydrochloride: An anti-HCV drug and a potential …

YM Ahmed, SS Badawy, FM Abdel-Haleem - Microchemical Journal, 2022 - Elsevier
Daclatasvir dihydrochloride (DAC) is an anti-hepatitis C virus (HCV) drug that has recently
proven to be a promising candidate for the treatment of SARS-CoV-2. Still, there is a lack of …

[HTML][HTML] Small-molecule antiviral treatments for COVID-19: A systematic review and network meta-analysis

B Zheng, Q Zhao, W Yang, P Feng, C **n, Y Ying… - International Journal of …, 2024 - Elsevier
Objective This study aimed to explore the efficacy and safety of small-molecule antivirals for
treating coronavirus disease 2019 (COVID-19). Methods Seven databases were searched …