Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Glucocorticoids regulate many physiological processes and have an essential role in the
systemic response to stress. For example, gene transcription is modulated by the …

Chronic inflammatory diseases of almost any cause are associated with bone loss. Bone
loss is due to direct effects of inflammation, poor nutrition, reduced lean body mass …

Glucocorticoids are steroid hormones that once bound to their receptor interact with the DNA
binding domain. Almost 1000–2000 genes are sensitive to their effects, including …

Context: 11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes are now appreciated to
be important regulators of hormone action at a tissue level. 11β-HSD1 is widely expressed …

Glucocorticoids (GCs) are known inhibitors of wound healing. In this study we report the
novel finding that both keratinocytes in vitro and epidermis in vivo synthesize cortisol and …

Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …

The metabolic abnormalities found associated with high blood glucocorticoid levels (eg rare
Cushing's syndrome) include insulin-resistance, visceral obesity, hypertension …

Background We investigated two distinct synovial fibroblast populations that were located
preferentially in the lining or sub-lining layers and defined by their expression of either …