Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the
last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in …

Escherichia coli (E. coli) is a gram-negative bacillus and resident of the normal intestinal
microbiota. However, some E. coli strains can cause diseases in humans, other mammals …

Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

New molecular modeling approaches, driven by rapidly improving computational platforms,
have allowed many success stories for the use of computer-assisted drug design in the …

Besides genetic polymorphisms and environmental factors, the intestinal microbiota is an
important factor in the etiology of Crohn's disease (CD). Among microbiota alterations, a …

Objective We used the postoperative recurrence model to better understand the role of
adherent and invasive Escherichia coli (AIEC) bacteria in Crohn's disease (CD), taking …

The mammalian intestine is colonized by trillions of microorganisms that are collectively
referred to as the gut microbiota. The majority of symbionts have co-evolved with their host in …

Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of
urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 …

The emergence of drug-resistant pathogens has led to a decline in the efficacy of traditional
antimicrobial therapy. The rise in resistance has been driven by widespread use, and in …

ABSTRACT Introduction: The bacterial adhesin FimH is a virulence factor and an attractive
therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type …