Solid tumours comprise cancer cells that engage in continuous interactions with non-
malignant cells and with acellular components, forming the tumour microenvironment (TME) …

Reactive oxygen species (ROS) are a group of highly active molecules produced by normal
cellular metabolism and play a crucial role in the human body. In recent years, researchers …

Metabolic reprogramming provides tumors with an energy source and biofuel to support
their survival in the malignant microenvironment. Extensive research into the intrinsic …

Pancreatic cancer is a devastating malignancy with a high mortality rate, poor prognosis,
and limited treatment options. The tumor microenvironment (TME) plays a crucial role in …

The interaction between the tumor microenvironment (TME) and the cancer cells is a
complex and mutually beneficial system that leads to rapid cancer cells proliferation …

Immunotherapy has emerged as promising treatment in sarcomas, but the high variability in
terms of histology, clinical behavior and response to treatments determines a particular …

Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer
and a crucial determinant of tumor progression. Research indicates that various metabolic …

Regulatory T cells (Tregs), a subset of CD4+ T cells marked by the expression of the
transcription factor forkhead box protein 3 (Foxp3), are pivotal in maintaining immune …

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis
and treatment response. It consists of diverse cell types, extracellular matrix components …

Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in
connective tissues embryologically derived from the mesenchyme. Due to their rarity, crucial …