Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …

The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of develo**
several of the major health issues facing the western world, including neurodegenerative …

In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for develo** cardiovascular disease because of the …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in
regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …

Ageing is due to an accumulation of various types of damage,, and mitochondrial
dysfunction has long been considered to be important in this process,,,,,. There is substantial …