Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …

The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis
resistance and be therapeutically targeted. Compared to normal cells, several human …

Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction
and vascular remodeling obstruct small pulmonary arteries, resulting in increased …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Background—The cause of pulmonary arterial hypertension (PAH) was investigated in
humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain …