Enhanced GABAergic neurotransmission contributes to impairment of motor coordination
and gait and of cognitive function in different pathologies, including hyperammonemia and …

Abstract Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation
and/or regulation of numerous physiological processes and psychiatric disorders (eg …

Currently available antidepressants have a substantial time lag to induce therapeutic
response and a relatively low efficacy. The development of drugs that addresses these …

The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating
anxiety-and panic-related responses. Given the cellular and behavioral evidence …

The vulnerability of epigenetic marks of brain cells to environmental stimuli and its
implication for health have been recently debated. Thus, we used the rat model of acute …

Typically the monoamine system has been the central focus of neurobiological research into
depression and represents the major target of modern antidepressant medications; although …

The review presents data which provides evidence for the internal relationship between the
stages of rodent audiogenic seizures and post-ictal catalepsy with the general pattern of …

Mood disorders are the most common mental disorders, affecting approximately 350 million
people globally. Recent studies have shown that neuroimmune interaction regulates mood …

Abstract The ketamine metabolite (2 R, 6R)-hydroxynorketamine (HNK) has recently been
suggested as an ideal antidepressant for treating animal models of depression. However, its …

The GABAergic neuroplasticity dysfunction (GND) has been proposed as a distinct
pathology for late-life anxiety disorder (LLAD). Brain-derived neurotrophic factor (BDNF) is a …