The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-
cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual …

The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common
medications and is an emerging public health issue,–. Patients with TEN undergo severe …

Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization
mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous map** of …

The emergence of spatial multi-omics has helped address the limitations of single-cell
sequencing, which often leads to the loss of spatial context among cell populations …

Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …