Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

Central sensitization is an increased responsiveness of nociceptive neurons in the central
nervous system to their normal or subthreshold afferent input. Aim: To explain how the …

Stress is a significant risk factor for the development of major depressive disorder (MDD), yet
the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress …

To calibrate or not to calibrate? This question is raised by almost everyone designing an
experimental pain study with supra-threshold stimulation. The dilemma is whether to …

To understand neurochemical brain responses to pain, proton magnetic resonance
spectroscopy (1H-MRS) is used in humans in vivo to examine various metabolites. Recent …

A growing body of evidence from neuroimaging studies suggests that inflammatory bowel
disease (IBD) is associated with functional and structural alterations in the central nervous …

A large body of molecular and neurophysiological evidence connects synaptic plasticity to
specific functions and energy metabolism in particular areas of the brain. Furthermore …

Aberrant neuronal excitability in the anterior cingulate cortex (ACC) is implicated in cognitive
and affective pain processing. Such excitability may be amplified by activated circulating …

Neuropathic pain often leads to negative emotions, which in turn can enhance the sensation
of pain. This study aimed to investigate the molecular mechanisms mediating neuropathic …

Background Fibromyalgia is a centralized multidimensional chronic pain syndrome, but its
pathophysiology is not fully understood. Methods We applied 3D magnetic resonance …