Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

Noteworthy perspectives on microglia in neuropsychiatric disorders

H Zhu, A Guan, J Liu, L Peng, Z Zhang… - Journal of …, 2023 - Springer
Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

YY Li, SF Ji, XB Fu, YF Jiang, XY Sun - Military Medical Research, 2024 - Springer
Scar formation resulting from burns or severe trauma can significantly compromise the
structural integrity of skin and lead to permanent loss of skin appendages, ultimately …

[HTML][HTML] Mechanosensation in traumatic brain injury

CE Keating, DK Cullen - Neurobiology of disease, 2021 - Elsevier
Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

SAU Shinge, D Zhang, AU Din, FX Yu… - International journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Purpose of Review: Atherosclerosis is the principal cause of cardiovascular diseases
(CVDs) which are the major cause of death worldwide. Mechanical force plays an essential …

Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis

YQ Zhao, XW Deng, GQ Xu, J Lin, HZ Lu… - Frontiers in Molecular …, 2023 - frontiersin.org
Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis.
Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular …

Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease

EK Mitten, G Baffy - Journal of Hepatology, 2022 - Elsevier
Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …

The relationship between cancer and biomechanics

L Bao, H Kong, Y Ja, C Wang, L Qin, H Sun… - Frontiers in …, 2023 - frontiersin.org
The onset, development, diagnosis, and treatment of cancer involve intricate interactions
among various factors, spanning the realms of mechanics, physics, chemistry, and biology …

The role of mechanotransduction in contact inhibition of locomotion and proliferation

F Nakamura - International Journal of Molecular Sciences, 2024 - mdpi.com
Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …

The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia

T Zhu, J Guo, Y Wu, T Lei, J Zhu, H Chen, S Kala… - Iscience, 2023 - cell.com
Microglia are the brain's resident immune cells, performing surveillance to promote
homeostasis and healthy functioning. While microglial chemical signaling is well-studied …