Microtubule-associated proteins (MAPs) function to regulate the assembly dynamics and
organization of microtubule polymers. Upstream regulation of MAP activities is the major …

α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common
feature of several neurodegenerative diseases. Two missense mutations in the α-synuclein …

A good approximation of the atomic structure of a microtubule has been derived from
docking the high-resolution structure of tubulin, solved by electron crystallography, into …

Structural and biochemical alterations of the microtubule‐associated protein tau (MAPT) are
associated with degenerative disorders referred to as tauopathies. We have previously …

We model the dynamical states of the C-termini of tubulin dimers that comprise neuronal
microtubules. We use molecular dynamics and other computational tools to explore the time …

Actin-microtubule crosstalk is implicated in the formation of cellular protrusions, but the
mechanism remains unclear. In this study, we examined the regulation of cell protrusion …

Microtubule is an important structural and functional component in cells. Microtubule-
associated proteins (MAPs) are a class of proteins that can bind to microtubules and …

Individual microtubules (MTs) repeat alternating phases of polymerization and
depolymerization, a process known as dynamic instability. Microtubule-associated proteins …

Although recent studies have suggested the role of microtubule-associated protein (MAP) 4
in some neuron-specific events, there are no reports that directly observed its neuronal …

The microtubule-binding domain of MAP4, a ubiquitous microtubule-associated protein,
contains a Repeat region with tandemly organized repeat sequences. In this study, we …