Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Y Nagahama, T Chakraborty… - Physiological …, 2021 - journals.physiology.org
A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …
J Guo, E Sosa, T Chitiashvili, X Nie, EJ Rojas, E Oliver… - Cell Stem Cell, 2021 - cell.com
Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
Sry: the master switch in mammalian sex determination
SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex
determination. Recent studies in mice reveal that the major role of SRY is to achieve …
determination. Recent studies in mice reveal that the major role of SRY is to achieve …
Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos
Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the
pathogenesis of common late-onset disorders, but how they arise is not clear,. Here we …
pathogenesis of common late-onset disorders, but how they arise is not clear,. Here we …