Regulation of autophagy by ROS: physiology and pathology

R Scherz-Shouval, Z Elazar - Trends in biochemical sciences, 2011 - cell.com
Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize
proteins, lipids and DNA. When tightly controlled, ROS serve as signaling molecules by …

The role of reactive oxygen species (ROS) in the formation of extracellular traps (ETs) in humans

W Stoiber, A Obermayer, P Steinbacher… - Biomolecules, 2015 - mdpi.com
Extracellular traps (ETs) are reticulate structures of extracellular DNA associated with
antimicrobial molecules. Their formation by phagocytes (mainly by neutrophils: NETs) has …

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

A Beatty, T Singh, YY Tyurina, VA Tyurin… - Nature …, 2021 - nature.com
Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of
polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 …

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis …

YQ Shen, A Guerra‐Librero… - Journal of pineal …, 2018 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt
mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of …

Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease

B Sid, J Verrax, PB Calderon - Biochemical pharmacology, 2013 - Elsevier
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of
alcohol-induced liver disease (ALD) is a multifactorial process that involves a number of …

Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death

ZG Leng, SJ Lin, ZR Wu, YH Guo, L Cai, HB Shang… - Autophagy, 2017 - Taylor & Francis
Dopamine agonists such as bromocriptine and cabergoline have been successfully used in
the treatment of pituitary prolactinomas and other neuroendocrine tumors. However, their …

Sequestered SQSTM1/p62 crosstalk with Keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis

H Gou, X Chen, X Zhu, L Li, L Hou, Y Zhou… - Free Radical Biology and …, 2022 - Elsevier
Periodontitis is a recognized multifactorial inflammatory chronic disease, however, the exact
role of oxidative stress in the pathogenesis of periodontitis is undefined. This study aims to …

Conjugated linolenic acids: implication in cancer

KK Dhar Dubey, G Sharma… - Journal of agricultural and …, 2019 - ACS Publications
Conjugated fatty acids (CFAs) including both conjugated linoleic acids (CLAs) and
conjugated linolenic acids (CLNAs) have various health promoting effects. These beneficial …

Cold atmospheric pressure plasma treatment combined with starvation increases autophagy and apoptosis in melanoma in vitro and in vivo

M Golpour, M Alimohammadi… - Experimental …, 2022 - Wiley Online Library
Despite advances in therapy, malignant melanoma remains a fatal disease. Among several
emerging approaches to combat cancer, cold atmospheric pressure plasma (CAP) has …

Elaborating the role of natural products‐induced autophagy in cancer treatment: achievements and artifacts in the state of the art

N Wang, Y Feng - BioMed research international, 2015 - Wiley Online Library
Autophagy is a homeostatic process that is highly conserved across different types of
mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress …