Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Caveolae, a subset of membrane (lipid) rafts, are flask-like invaginations of the plasma
membrane that contain caveolin proteins, which serve as organizing centers for cellular …

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by
activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1) …

Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

Morphological change is one of the cardinal features of the senescent phenotype; for
example, senescent human diploid cells have a flat large shape. However, the mechanisms …

Cellular senescence is a feature of most somatic cells. It is characterized by an irreversible
cell cycle arrest and by the ability to secrete a plethora of mediators of inflammation and …

Objective Articular chondrocyte senescence is responsible, at least in part, for the increased
incidence of osteoarthritis (OA) with increased age. Recently, it was suggested that caveolin …

The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging
topic in aging research. Our comprehensive data mining revealed over 250 genes tightly …

The efficiency of signal transduction in cells derives in part from subcellular, in particular
plasma membrane, microdomains that organize signaling molecules and signaling …