Diabetic kidney disease (DKD) is a leading diabetic complication causing significant
mortality among people around the globe. People with poor glycemic control accompanied …

Although great efforts have been made to elucidate the pathological mechanisms of renal
diseases and potential prevention and treatment targets that would allow us to retard kidney …

Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with
pyroptosis, a type of inflammation-regulated cell death. The purpose of this work was to …

Obesity-associated diabetes is linked to the accumulation of ceramide in various organs,
including the liver. The exact mechanisms by which ceramide contributes to diabetic …

Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …

Aims To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility
among high-risk populations with type 2 diabetes mellitus. Methods KDIGO (Kidney …

Cell deaths maintain the normal function of tissues and organs. In pathological conditions,
the abnormal activation or disruption of cell death often leads to pathophysiological effects …

Abstract Background Type 1 diabetes (T1D) is an organ-specific autoimmune disorder
characterized by the destruction of pancreatic β cells, leading to absolute insulin deficiency …

Podocyte damage plays a crucial role in the occurrence and development of diabetic
nephropathy (DN). Accumulating evidence suggests that dysregulation of transcription …

Focal cortical dysplasia (FCD) is recognized as a significant etiological factor in
pharmacoresistant intractable epilepsy, linked with disturbances in neurovascular …