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Regulation of neutrophil NADPH oxidase, NOX2: a crucial effector in neutrophil phenotype and function
MH Paclet, S Laurans, S Dupré-Crochet - Frontiers in Cell and …, 2022 - frontiersin.org
Reactive oxygen species (ROS), produced by the phagocyte NADPH oxidase, NOX2, are
involved in many leukocyte functions. An excessive or inappropriate ROS production can …
involved in many leukocyte functions. An excessive or inappropriate ROS production can …
Immunity to pathogenic fungi in the eye
S Abbondante, SM Leal, HL Clark, B Ratitong… - Seminars in …, 2023 - Elsevier
Abstract Fusarium, Aspergillus and Candida are important fungal pathogens that cause
visual impairment and blindness in the USA and worldwide. This review will summarize the …
visual impairment and blindness in the USA and worldwide. This review will summarize the …
Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase
Z Song, S Bhattacharya, RA Clemens, MC Dinauer - Iscience, 2023 - cell.com
Neutrophil swarming is a complex coordinated process in which neutrophils sensing
pathogen or damage signals are rapidly recruited to sites of infections or injuries. This …
pathogen or damage signals are rapidly recruited to sites of infections or injuries. This …
Neutrophil and macrophage NADPH oxidase 2 differentially control responses to inflammation and to Aspergillus fumigatus in mice
RA Idol, S Bhattacharya, G Huang, Z Song… - The Journal of …, 2022 - journals.aai.org
Aspergillus fumigatus is an important opportunistic fungal pathogen and causes invasive
pulmonary aspergillosis in conditions with compromised innate antifungal immunity …
pulmonary aspergillosis in conditions with compromised innate antifungal immunity …
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
K Wang, V Espinosa, A Rivera - Current Opinion in Immunology, 2023 - Elsevier
The detrimental impact of fungal infections to human health has steadily increased over the
past decades. In October of 2022, the World Health Organization published the first ever …
past decades. In October of 2022, the World Health Organization published the first ever …
NADPH oxidase 2 limits amplification of IL-1β–G-CSF axis and an immature neutrophil subset in murine lung inflammation
Z Song, S Bhattacharya, G Huang… - Blood …, 2023 - ashpublications.org
The leukocyte NADPH oxidase 2 (NOX2) regulates inflammation independent of its
antimicrobial activity. Inherited defects in NOX2 lead to chronic granulomatous disease …
antimicrobial activity. Inherited defects in NOX2 lead to chronic granulomatous disease …
Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease
N Kordana, A Johnson, K Quinn, JJ Obar… - Microbiology and …, 2025 - journals.asm.org
Advances in modern medical therapies for many previously intractable human diseases
have improved patient outcomes. However, successful disease treatment outcomes are …
have improved patient outcomes. However, successful disease treatment outcomes are …
New developments in Aspergillus fumigatus and host reactive oxygen species responses
MR James, KE Doss, RA Cramer - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Host immune states with changes in reactive oxygen species favor A. fumigatus
infection.•General A. fumigatus stress response regulators impact susceptibility to …
infection.•General A. fumigatus stress response regulators impact susceptibility to …
[HTML][HTML] Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections
The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial
uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study …
uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study …
Lupus-associated NCF2 variant p. R395W in the NADPH oxidase 2 complex results in a reduced production of reactive oxygen species by myeloid cells
Z Song, DG Yoo, RA Idol, EA Barbu, CO Jacob… - Frontiers in …, 2023 - frontiersin.org
The leukocyte NADPH oxidase 2 (NOX2) generates superoxide, and derivative reactive
oxygen species play important roles in both host defense and immunoregulation. The …
oxygen species play important roles in both host defense and immunoregulation. The …