▪ Abstract PDZ domains are modular protein interaction domains that bind in a sequence-
specific fashion to short C-terminal peptides or internal peptides that fold in a β-finger. The …

PDZ domains1 are modular protein interaction domains that play a role in protein targeting
and protein complex assembly. Once termed Discs-large homology regions (DHRs) or …

Excitatory synapses in the brain exhibit a remarkable degree of functional plasticity, which
largely reflects changes in the number of synaptic α-amino-3-hydroxy-5-methyl-4 …

Stroke is a major public health problem leading to high rates of death and disability in
adults,. Excessive stimulation of N-methyl-d-aspartate receptors (NMDARs) and the resulting …

Abstract The Human Papillomavirus (HPV) E6 protein is one of three oncoproteins encoded
by the virus. It has long been recognized as a potent oncogene and is intimately associated …

Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …

Nitric oxide (NO), a molecular messenger synthesized by nitric oxide synthase (NOS) from L-
arginine and molecular oxygen, is involved in a number of physiological and pathological …

The stress-activated protein kinase p38 and nitric oxide (NO) are proposed downstream
effectors of excitotoxic cell death. Although the postsynaptic density protein PSD95 can …

Syntenin is an adaptor-like molecule that binds to the cytoplasmic domains of all four
vertebrate syndecans. Syntenin-syndecan binding involves the C-terminal part of syntenin …

The LAP (leucine-rich repeatand PDZ-containing) family of proteins play a role in
maintaining epithelial and neuronal cell size, and mutation of these proteins can have …