Nucleoside triphosphates (NTPs and dNTPs, Figure 1) have important therapeutic and
diagnostic applications. Experience with syntheses of these compounds, and discussions …

Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving
mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the …

Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a
targeted manner via co-opted ubiquitin ligases have enormous potential to transform the …

Pacific Biosciences has developed a method for real-time sequencing of single DNA
molecules (Eid et al., 2009), with intrinsic sequencing rates of several bases per second and …

Analogs of the mRNA cap are widely employed to study processes involved in mRNA
metabolism as well as being useful in biotechnology and medicinal applications. Here we …

The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a
variety of applications. However, one-third to one-half of the caps have, until now, been …

The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome
coronavirus (SARS‐CoV‐2) emphasizes the importance of mRNA as a powerful tool for …

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ABSTRACT 5,846,737 A 12/1998 Kang 5,863,727 A 1/1999 Lee et al. The present invention …

Synthetic capped RNA transcripts produced by in vitro transcription in the presence of m 7
Gp 3 G have found a wide application in studying such processes as mRNA translation, pre …

mRNA-based vaccines are relatively new technologies that have been in the field of interest
of research centers and pharmaceutical companies in recent years. Such therapeutics are …