Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

Cytokines are proteins secreted in the central nervous system by neurons, microglia,
astrocytes and infiltrating peripheral immune cells under physiological and pathological …

Profound and debilitating fatigue is the most common complaint reported among individuals
with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 …

Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …

The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine
receptor 1 (CX3CR1) signaling in neurodegenerative disease is an intricate and highly …

Aiming at a formulation of a cytokine model of cognitive function under immunologically
unchallenged physiological conditions, this article reviews the cytokine biology in the central …

Major depressive disorder (MDD) is a complex illness and it is likely that alterations in
several interacting systems underlie its pathogenesis. Numerous hypotheses have been …

Sickness refers to a coordinated set of subjective, behavioural and physiological changes
that develop in sick individuals during the course of an infection. These changes are due to …

This review describes the role of cytokines and their downstream signaling cascades on the
modulation of learning and memory. Immune proteins are required for many key neural …