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Bis-and trisindolylmethanes (BIMs and TIMs)
The indole ring system is present in many natural products, pharmaceuticals,
agrochemicals, and other compounds of importance. 1–8 The indole unit forms the basis for …
agrochemicals, and other compounds of importance. 1–8 The indole unit forms the basis for …
Unlocking diversity: from simple to cutting-edge synthetic methodologies of bis (indolyl) methanes
From a synthetic perspective, bis (indolyl) methanes have undergone extensive
investigation over the past two to three decades owing to their remarkable pharmacological …
investigation over the past two to three decades owing to their remarkable pharmacological …
Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers
The aim of the current study was to encapsulate celecoxib (Cxb) in the nanostructured lipid
carrier (Cxb-NLC) nanoparticles and evaluate the lung disposition of nanoparticles following …
carrier (Cxb-NLC) nanoparticles and evaluate the lung disposition of nanoparticles following …
Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC
H Hu, J Chen, H Yang, X Huang, H Wu, Y Wu, F Li, Y Yi… - Nanoscale, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a clinically approved cancer treatment which utilizes reactive
oxygen species (ROS) to eradicate cancer cells. But the high concentration of GSH inside …
oxygen species (ROS) to eradicate cancer cells. But the high concentration of GSH inside …
Old wine in new bottles: Drug repurposing in oncology
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …
of de novo development of new anticancer drugs have prompted the pharmaceutical …
[HTML][HTML] Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer
Objective To test the anticancer potential activity of the combination of thymoquinone (TQ)
and resveratrol (RES) against breast cancer in mice. Methods The antiproliferative activity of …
and resveratrol (RES) against breast cancer in mice. Methods The antiproliferative activity of …
Attenuation of multi-targeted proliferation-linked signaling by 3, 3′-diindolylmethane (DIM): from bench to clinic
S Banerjee, D Kong, Z Wang, B Bao, GG Hillman… - … Research/Reviews in …, 2011 - Elsevier
Emerging evidence provide credible support in favor of the potential role of bioactive
products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts …
products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts …
[HTML][HTML] The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro
R Lowenthal, M Taylor, JA Gidden, B Heflin… - Biomedicine & …, 2023 - Elsevier
Melanoma is one of the most aggressive forms of skin cancer and is characterized by high
metastatic potential. Despite improvements in early diagnosis and treatment, the mortality …
metastatic potential. Despite improvements in early diagnosis and treatment, the mortality …
Organocatalytic enantioselective SN 1-type dehydrative nucleophilic substitution: access to bis (indolyl) methanes bearing quaternary carbon stereocenters
WR Zhu, Q Su, XY Deng, JS Liu, T Zhong, SS Meng… - Chemical …, 2022 - pubs.rsc.org
A highly general and straightforward approach to access chiral bis (indolyl) methanes (BIMs)
bearing quaternary stereocenters has been realized via enantioconvergent dehydrative …
bearing quaternary stereocenters has been realized via enantioconvergent dehydrative …
Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy
Indole compounds, obtained from cruciferous vegetables, have been investigated for their
putative anti-cancer properties. Studies with indole-3-carbinol (I3C) and its dimeric product …
putative anti-cancer properties. Studies with indole-3-carbinol (I3C) and its dimeric product …