Amelogenesis imperfecta; genes, proteins, and pathways
Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …
characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans'
for which endogenous ligands are unknown, and many have no selective ligands, hindering …
for which endogenous ligands are unknown, and many have no selective ligands, hindering …
Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop's classification
A Bloch-Zupan, T Rey, A Jimenez-Armijo… - Frontiers in …, 2023 - frontiersin.org
Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …
Regulation of inflammation by extracellular acidification and proton-sensing GPCRs
F Okajima - Cellular signalling, 2013 - Elsevier
Under ischemic and inflammatory circumstances, such as allergic airway asthma,
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
GPR68: an emerging drug target in cancer
GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-
protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a …
protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a …
Role of proton-activated G protein-coupled receptors in pathophysiology
Local acidification is a common feature of many disease processes such as inflammation,
infarction, or solid tumor growth. Acidic pH is not merely a sequela of disease but contributes …
infarction, or solid tumor growth. Acidic pH is not merely a sequela of disease but contributes …
Proton-sensing GPCRs in health and disease
The group of proton-sensing G-protein coupled receptors (GPCRs) consists of the four
receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors …
receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors …
[HTML][HTML] Extracellular vesicles in bone homeostasis: emerging mediators of osteoimmune interactions and promising therapeutic targets
X Huang, Y Lan, J Shen, Z Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
An imbalance in bone homeostasis results in bone loss and poor healing in bone diseases
and trauma. Osteoimmune interactions, as a key contributor to bone homeostasis, depend …
and trauma. Osteoimmune interactions, as a key contributor to bone homeostasis, depend …
Osteoclast stimulatory transmembrane protein (OC‐STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation
M Yang, MJ Birnbaum, CA MacKay… - Journal of cellular …, 2008 - Wiley Online Library
Microarray and real‐time RT‐PCR were used to examine expression changes in primary
bone marrow cells and RAW 264.7 cells in response to RANKL. In silico sequence analysis …
bone marrow cells and RAW 264.7 cells in response to RANKL. In silico sequence analysis …