A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

[HTML][HTML] lifex: A flexible, high performance library for the numerical solution of complex finite element problems

PC Africa - SoftwareX, 2022 - Elsevier
Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

[HTML][HTML] Clinical impact of computational heart valve models

M Toma, S Singh-Gryzbon, E Frankini, Z Wei… - Materials, 2022 - mdpi.com
This paper provides a review of engineering applications and computational methods used
to analyze the dynamics of heart valve closures in healthy and diseased states …

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

PC Africa, I Fumagalli, M Bucelli, A Zingaro… - Computer Physics …, 2024 - Elsevier
Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

The role of computational methods in cardiovascular medicine: a narrative review

I Fumagalli, S Pagani, C Vergara… - Translational …, 2024 - pmc.ncbi.nlm.nih.gov
Background and Objective Computational models of the cardiovascular system allow for a
detailed and quantitative investigation of both physiological and pathological conditions …

An image-based computational fluid dynamics study of mitral regurgitation in presence of prolapse

L Bennati, C Vergara, V Giambruno, I Fumagalli… - Cardiovascular …, 2023 - Springer
Purpose In this work we performed an imaged-based computational study of the systolic
fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared …

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

M Fedele, A Quarteroni - International Journal for Numerical …, 2021 - Wiley Online Library
In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

A Zingaro, I Fumagalli, L Dede, M Fedele… - arxiv preprint arxiv …, 2021 - arxiv.org
We present a new computational model for the numerical simulation of blood flow in the
human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian …

Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI

L Bennati, V Giambruno, F Renzi, V Di Nicola… - … and Modeling in …, 2023 - Springer
In this work, we performed a computational image-based study of blood dynamics in the
whole left heart, both in a healthy subject and in a patient with mitral valve regurgitation. We …