The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …

In mammals, the suprachiasmatic nucleus (SCN) functions as a circadian clock that drives
24-h rhythms in both physiology and behavior. The SCN is a multicellular oscillator in which …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

Featured Application This review summarizes current knowledge regarding the effects of
physical activity on the robustness of the circadian system and the benefits for health …

Fortunate are those who rise out of bed to greet the morning light well rested with the energy
and enthusiasm to drive a productive day. Others, however, depend on hypnotics for sleep …

Key points• The circadian system drives rhythms of behaviour, physiology and gene
expression in alignment to a light–dark cycle, and misalignment of the internal clock with the …

Exercise during the inactive period can entrain locomotor activity and peripheral circadian
clock rhythm in mice; however, mechanisms underlying this entrainment are yet to be …

Fatigue is a symptom associated with many disorders, is especially common in women and
in older adults, and can have a huge negative influence on quality of life. Although most past …

Sleep and circadian rhythm disruption (SCRD) and schizophrenia are often co-morbid.
Here, we propose that the co-morbidity of these disorders stems from the involvement of …

Circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), a small structure at
the base of the hypothalamus. While light effects on the SCN are well established, little is …