Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …

Endogenous biomolecular condensates, composed of a multitude of proteins and RNAs,
can organize into multiphasic structures with compositionally distinct phases. This …

Biomolecular phase separation denotes the demixing of a specific set of intracellular
components without membrane encapsulation. Recent studies have found that biomolecular …

Conformational properties of intrinsically disordered proteins (IDPs) are governed by a
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …

A theory for sequence-dependent liquid–liquid phase separation (LLPS) of intrinsically
disordered proteins (IDPs) in the study of biomolecular condensates is formulated by …

Intracellular condensates are highly multi-component systems in which complex phase
behaviour can ensue, including the formation of architectures comprising multiple …

Proteomic studies have shown that cellular condensates are frequently enriched in diverse
RNA molecules, which is suggestive of mechanistic links between phase separation and …

Biomolecules composed of a limited set of chemical building blocks can colocalize into
distinct, spatially segregated compartments known as biomolecular condensates. While …

Biomolecular condensates such as membraneless organelles, underpinned by liquid–liquid
phase separation (LLPS), are important for physiological function, with electrostatics, among …

Many membraneless organelles, or biological condensates, form through phase separation,
and play key roles in signal sensing and transcriptional regulation. While the functional …