Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth,
differentiation, function, and death. Considerable progress has been made in our …

Inactivation of β-catenin in mesenchymal progenitors prevents osteoblast differentiation;
inactivation of Lrp5, a gene encoding a likely Wnt coreceptor, results in low bone mass …

Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …

Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture.
Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …