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Bifunctional stapled polypeptides and uses thereof
GL Verdine, TN Grossmann, RE Moellering… - US Patent …, 2015 - Google Patents
2010-11-15 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Stabilized p53 peptides and uses thereof
US8889632B2 - Stabilized p53 peptides and uses thereof - Google Patents US8889632B2 -
Stabilized p53 peptides and uses thereof - Google Patents Stabilized p53 peptides and uses …
Stabilized p53 peptides and uses thereof - Google Patents Stabilized p53 peptides and uses …
Peptidomimetic macrocycles with improved properties
HM Nash, DA Annis, R Kapeller-Libermann… - US Patent …, 2016 - Google Patents
The present invention provides biologically active peptido mimetic macrocycles with
improved properties relative to their corresponding polypeptides. The invention additionally …
improved properties relative to their corresponding polypeptides. The invention additionally …
Stabilized alpha helical peptides and uses thereof
LD Walensky, SJ Korsmeyer, G Verdine - US Patent 9,273,099, 2016 - Google Patents
Novel polypeptides and methods of making and using the same are described herein. The
polypeptides include cross linking (“hydrocarbon stapling) moieties to provide a tether …
polypeptides include cross linking (“hydrocarbon stapling) moieties to provide a tether …
Stabilized alpha helical peptides and uses thereof
LD Walensky, SJ Korsmeyer, G Verdine - US Patent 9,464,115, 2016 - Google Patents
Related US Application Data (63) Continuation of application No. 13/252,751, filed on Oct. 4,
2011, now Pat. No. 9,273,099, which is a continuation of application No. 12/233,555, filed on …
2011, now Pat. No. 9,273,099, which is a continuation of application No. 12/233,555, filed on …
Stitched polypeptides
GL Verdine, YW Kim - US Patent 9,556,227, 2017 - Google Patents
2015-11-02 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Stabilized compounds having secondary structure motifs
GL Verdine, CE Schafmeister - US Patent 9,505,801, 2016 - Google Patents
The present invention provides novel stabilized crosslinked compounds having secondary
structure motifs, libraries of these novel compounds, and methods for the synthesis of these …
structure motifs, libraries of these novel compounds, and methods for the synthesis of these …
Proline-locked stapled peptides and uses thereof
GL Verdine, K Hayashi - US Patent 9,617,309, 2017 - Google Patents
2014-03-04 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Ligation of stapled polypeptides
GL Verdine, EJ Kennedy - US Patent 9,458,189, 2016 - Google Patents
The present invention provides technology for making large (eg, greater than 50 amino
acids), semi-synthetic, Stapled or stitched proteins. The method essentially involves ligat ing …
acids), semi-synthetic, Stapled or stitched proteins. The method essentially involves ligat ing …
Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
V Guerlavais, CR Conlee, SP Lentini - US Patent 8,987,414, 2015 - Google Patents
US8987414B2 - Triazole-crosslinked and thioether-crosslinked peptidomimetic
macrocycles - Google Patents US8987414B2 - Triazole-crosslinked and thioether-crosslinked …
macrocycles - Google Patents US8987414B2 - Triazole-crosslinked and thioether-crosslinked …