Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: a prospective cohort study

Y Wang, L Yang, H Bao, X Fan, F **a, J Wan… - PLoS …, 2021 - journals.plos.org
Background For locally advanced rectal cancer (LARC) patients who receive neoadjuvant
chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict …

A diagnostic biopsy-adapted immunoscore predicts response to neoadjuvant treatment and selects patients with rectal cancer eligible for a watch-and-wait strategy

C El Sissy, A Kirilovsky, M Van den Eynde… - Clinical Cancer …, 2020 - aacrjournals.org
Purpose: No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is
currently available. We assessed in LARC whether a diagnostic biopsy-adapted …

International validation of the immunoscore biopsy in patients with rectal cancer managed by a watch-and-wait strategy

C El Sissy, A Kirilovsky, C Lagorce Pagès… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE No biomarker capable of improving selection and monitoring of patients with
rectal cancer managed by watch-and-wait (W&W) strategy is currently available. Prognostic …

The crying need for a better response assessment in rectal cancer

S Amintas, N Giraud, B Fernandez, C Dupin… - … treatment options in …, 2023 - Springer
Opinion statement Since total neoadjuvant treatment achieves almost 30% pathologic
complete response, organ preservation has been increasingly debated for good responders …

A comprehensive evaluation of associations between routinely collected staging information and the response to (chemo) radiotherapy in rectal cancer

K Hammarström, I Imam, A Mezheyeuski, J Ekström… - Cancers, 2020 - mdpi.com
Simple Summary Rectal cancer patients are often treated with radiotherapy, either alone or
combined with chemotherapy, prior to surgery to enable radical surgery on a non-resectable …

Assessing the predictive value of clinical factors to pathological complete response for locally advanced rectal cancer: An analysis of 124 patients

C Zhou, K Wang, X Zhang, Y **ao, C Yang… - Frontiers in …, 2023 - frontiersin.org
Purpose To investigate the clinical factors affecting pathological complete response (pCR)
after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) …

Collaboration in colorectal surgical research

J Rosenberg, E Angenete, T Pinkney, A Bhangu… - 2021 - Wiley Online Library
Surgical research has been under‐powered, under‐funded and under‐delivered for
decades. A solution may be to form large research collaborations and thereby enable …

Long-term outcome in a phase II study of regional hyperthermia added to preoperative radiochemotherapy in locally advanced and recurrent rectal adenocarcinomas

BC Schem, F Pfeffer, MA Ott, JN Wiig, N Sletteskog… - Cancers, 2022 - mdpi.com
Simple Summary Regional hyperthermia added to standard preoperative
chemoradiotherapy for locally advanced and recurrent rectal cancer gives a high complete …

ctDNA responds to neoadjuvant treatment in locally advanced rectal cancer

F Bürtin, L Elias, S Hinz, M Forster… - Journal of Cancer …, 2024 - Springer
Background Liquid biopsy is a minimally invasive procedure investigating tumor mutations.
Methods In our retrospective study, we investigated whether molecular therapy monitoring of …

Pilot proteomic study of locally advanced rectal cancer before and after neoadjuvant chemoradiotherapy indicates high metabolic activity in non‐responders' tumor …

T Babic, V Lygirou, J Rosic, M Miladinov… - PROTEOMICS …, 2023 - Wiley Online Library
Purpose In the search for candidate predictive biomarkers to evaluate response to
neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, only a few studies report …