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Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: a prospective cohort study
Background For locally advanced rectal cancer (LARC) patients who receive neoadjuvant
chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict …
chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict …
A diagnostic biopsy-adapted immunoscore predicts response to neoadjuvant treatment and selects patients with rectal cancer eligible for a watch-and-wait strategy
Purpose: No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is
currently available. We assessed in LARC whether a diagnostic biopsy-adapted …
currently available. We assessed in LARC whether a diagnostic biopsy-adapted …
International validation of the immunoscore biopsy in patients with rectal cancer managed by a watch-and-wait strategy
C El Sissy, A Kirilovsky, C Lagorce Pagès… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE No biomarker capable of improving selection and monitoring of patients with
rectal cancer managed by watch-and-wait (W&W) strategy is currently available. Prognostic …
rectal cancer managed by watch-and-wait (W&W) strategy is currently available. Prognostic …
The crying need for a better response assessment in rectal cancer
Opinion statement Since total neoadjuvant treatment achieves almost 30% pathologic
complete response, organ preservation has been increasingly debated for good responders …
complete response, organ preservation has been increasingly debated for good responders …
A comprehensive evaluation of associations between routinely collected staging information and the response to (chemo) radiotherapy in rectal cancer
K Hammarström, I Imam, A Mezheyeuski, J Ekström… - Cancers, 2020 - mdpi.com
Simple Summary Rectal cancer patients are often treated with radiotherapy, either alone or
combined with chemotherapy, prior to surgery to enable radical surgery on a non-resectable …
combined with chemotherapy, prior to surgery to enable radical surgery on a non-resectable …
Assessing the predictive value of clinical factors to pathological complete response for locally advanced rectal cancer: An analysis of 124 patients
C Zhou, K Wang, X Zhang, Y **ao, C Yang… - Frontiers in …, 2023 - frontiersin.org
Purpose To investigate the clinical factors affecting pathological complete response (pCR)
after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) …
after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) …
Collaboration in colorectal surgical research
Surgical research has been under‐powered, under‐funded and under‐delivered for
decades. A solution may be to form large research collaborations and thereby enable …
decades. A solution may be to form large research collaborations and thereby enable …
Long-term outcome in a phase II study of regional hyperthermia added to preoperative radiochemotherapy in locally advanced and recurrent rectal adenocarcinomas
BC Schem, F Pfeffer, MA Ott, JN Wiig, N Sletteskog… - Cancers, 2022 - mdpi.com
Simple Summary Regional hyperthermia added to standard preoperative
chemoradiotherapy for locally advanced and recurrent rectal cancer gives a high complete …
chemoradiotherapy for locally advanced and recurrent rectal cancer gives a high complete …
ctDNA responds to neoadjuvant treatment in locally advanced rectal cancer
F Bürtin, L Elias, S Hinz, M Forster… - Journal of Cancer …, 2024 - Springer
Background Liquid biopsy is a minimally invasive procedure investigating tumor mutations.
Methods In our retrospective study, we investigated whether molecular therapy monitoring of …
Methods In our retrospective study, we investigated whether molecular therapy monitoring of …
Pilot proteomic study of locally advanced rectal cancer before and after neoadjuvant chemoradiotherapy indicates high metabolic activity in non‐responders' tumor …
T Babic, V Lygirou, J Rosic, M Miladinov… - PROTEOMICS …, 2023 - Wiley Online Library
Purpose In the search for candidate predictive biomarkers to evaluate response to
neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, only a few studies report …
neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, only a few studies report …