Polycyclic aromatic hydrocarbons (PAHs) are ubiquitously distributed environmental
chemicals. PAHs acquire carcinogenicity only after they have been activated by xenobiotic …

Polycyclic aromatic hydrocarbons (PAHs) are a class of widespread environmental
carcinogens. Most of our knowledge of their mechanisms of metabolic activation to DNA …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …

Microsomal cytochrome P450 family 1 enzymes play prominent roles in xenobiotic
detoxication and procarcinogen activation. P450 1A2 is the principal cytochrome P450 …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …

Cytochrome P450 CYP1B1 is a relatively recently identified member of the CYP1 gene
family. The purpose of this commentary is to review the regulatory mechanisms, metabolic …