Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …

Articular cartilage injury is a prevalent clinical condition resulting from trauma, tumors,
infection, osteoarthritis, and other factors. The intrinsic lack of blood vessels, nerves, and …

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects
and osteoarthritic lesions, consequently advances in innovative therapeutics are required …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …

Most of our bones form through the process of endochondral ossification, which is tightly
regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the …

In recent years, there has been a great deal of interest in the development of regenerative
approaches to produce hyaline cartilage ex vivo that can be utilized for the repair or …

Nanofat (NF) is a fine emulsion that has been used to treat a variety of diseases given its
abundance of bioactive components. However, the biological functions of NF have been …

Chondrocytes provide the framework for the develo** skeleton and regulate long‐bone
growth through the activity of the growth plate. Chondrocytes in the articular cartilage, found …

Epigenetic regulation of gene expression, through covalent modification of histones, is a key
process controlling growth and development. Accordingly, the transcription factors …