RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

BACKGROUND Genomes are subject to two types of changes: changes to the DNA
sequence, and changes that are epigenetic in nature. Changes to the DNA sequence can …

Codon optimization describes gene engineering approaches that use synonymous codon
changes to increase protein production. Applications for codon optimization include …

Prostate cancer antigen 3 (PCA3) is the most specific prostate cancer biomarker but its
function remains unknown. Here we identify PRUNE2, a target protein-coding gene variant …

Productive herpesvirus infection requires a profound, time-controlled remodeling of the viral
transcriptome and proteome. To gain insights into the genomic architecture and gene …

The reliable detection of RNA editing sites from massive sequencing data remains
challenging and, although several methodologies have been proposed, no computational …

RNA editing is a widespread post-transcriptional mechanism able to modify transcripts
through insertions/deletions or base substitutions. It is prominent in mammals, in which …

A-to-I editing is the most prevalent RNA editing event, which refers to the change of
adenosine (A) bases to inosine (I) bases in double-stranded RNAs. Several studies have …

This paper concerns 3′-untranslated regions (3′ UTRs) of mRNAs, which are non-coding
regulatory platforms that control stability, fate and the correct spatiotemporal translation of …

The accurate and thorough genome-wide detection of adenosine-to-inosine editing, a
biologically indispensable process, has proven challenging. Here, we present a discovery …